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Myelodysplastic Syndrome

Myelodysplastic syndrome (MDS, also known as Preleukemia) is a diverse collection of hematologic conditions united by poor production of blood cells. Often referred to as Pre-leukemia, if not treated Myelodysplastic Syndrome can result in "Secondary Leukemia."

signs of myelodysplastic syndrome:
  • neutropenia - The presence of an abnormally small number of neutrophil cells in the blood.
  • anaemia - A reduction in the number of circulating red blood cells per volume of blood. Anemia requiring chronic blood transfusion is frequently present.
  • thrombocytopenia - An abnormal disease in the number of blood platelets.
  • abnormal granules in cells - A minute mass in a cell that has an outline but no apparent structure, also known as granulatio.
  • abnormal nuclear shape and size - Deformity of the structure within a cell that contains the chromosomes. As the nucleus is responsible for the cell's metabolism, growth, and reproduction. Deformities of the nucleus can negatively affect these functions.
  • chromosomal abnormalities, including chromosomal translocations.
symptoms of myelodysplastic syndrome:

The following list of myelodysplastic symptoms does not in itself confirm the diagnosis of the syndrome. The symptoms can be a result of many diseases and other related syndromes. For diagnosis, the clinical exams at the bottom of the article would be required.

  • Anaemia - A reduction in the number of circulating red blood cells per volume of blood produces:
    • chronic tiredness
    • shortness of breath
    • chilled sensation
  • Occasional chest pain in some patients.
  • Neutropenia (low white cell count)
    • resulting in increased susceptibility to infection
  • Thrombocytopenia (low platelet count)
    • resulting in increased susceptibility to bleeding
Clinical Examinations for diagnosis of myelodysplastic syndrome

In a clinical setting, the following exams are used to confirm the diagnosis of MDS:

  • Full blood count and examination of blood film (CBC)
  • Bone marrow aspirate and biopsy
  • Chromosome studies
Disclaimer: Information shared in this section is indicative. Please do not make any conclusion and we strongly recommend you to consult with your Doctor. Symptoms may vary with individual, geography, climate and lifestyle